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These results, together with a prior report demonstrating that a small-molecule ACKR3 agonist CCX771 reveals anxiolytic-like behavior in mice,two aid the notion of targeting ACKR3 as a novel technique to modulate the opioid system, which could open up new therapeutic avenues for opioid-related Issues.Morphine and other opioids enhance the exercise
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Inside a recent review, we reported the identification and the characterization of a different atypical opioid receptor with one of a kind detrimental regulatory Attributes toward opioid peptides.one Our outcomes showed that ACKR3/CXCR7, hitherto generally known as an atypical scavenger receptor for chemokines CXCL12 and CXCL11, is also a wide-spec